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Maintenance dose: 20 mg orally once a day at bedtime. 3 Administration Instructions Take PEPCID once daily before bedtime or twice daily in the morning and before bedtime, as recommended. 16 YEARS AND OLDER: Oral: Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day. Duration of therapy: 4 weeks lack or loss of strength loss in sexual ability, desire, drive, or performance muscle pain or stiffness redness of the face, neck, arms and occasionally, upper chest redness of the white part of the eyes stomach discomfort unusual drowsiness For Healthcare Professionals. PEPCID may be taken with or without food [see Clinical Pharmacology (12. Pepcid AC, Zantac 360 (famotidine) dosing, indications, interactions, adverse effects, and more acalabrutinib Monitor Closely (1)famotidine decreases levels of acalabrutinib by increasing gastric pH. 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